Welcome to the Karch Lab!
Our Scientific Mission
The goal of the Karch lab is to understand the molecular drivers of Alzheimer’s disease, frontotemporal dementia, and other neurodegenerative disease. To do this, we use functional genomics along side stem cell and mouse models. The Karch lab has developed a somatic and stem cell collection containing deeply clinically characterized cell lines from individuals carrying genetic drivers of Alzheimer’s disease, frontotemporal dementia, amyotrophic lateral sclerosis and Parkinson’s disease. These cells are used to develop novel tools to interrogate mechanisms of neurodegenerative disease. Additionally, the Karch lab couples high-throughput transcriptomics and proteomics in stem cells and human brain tissues to identify disease signatures and to understand protein kinetics in disease.
Our Diversity, Equity, and Inclusion Mission
Our goal is to perform cutting-edge research to understand and cure neurodegenerative disease, while advocating for equity and representation within and beyond the lab
- To evaluate, challenge, and build-upon developments and contributions to the field of neurodegenerative research
- To address questions that are medically and socially relevant
- To develop a stem cell repository representative of the breadth of individuals affected by neurodegenerative disease
- To provide mentorship that ensures lab members are thoroughly trained to approach scientific inquiry in a methodical and hypothesis-driven manner; while simultaneously fostering the development of skills necessary to empower themselves and to accomplish their career goals.
- To foster an environment that values and rewards collaboration, sharing and teamwork
- Commitment to Diversity, Inclusion, and Equity
- Dedication to Changing the Landscape of the Future of Neurodegenerative Research
- Growth, Support, and Training Initiatives
- Building Trust