Resources

Protocols

A detailed protocol is a key component of maintaining rigor and reproducibility and supporting open science practices. Protocols.io allows us to develop, edit, and share our protocols. Access our protocols here.

Depiction of the ability to take Fibroblasts and reprogram them into Induced Pluripotent Stem Cells (iPSCs). After the production of iPSCs, the following cell types can be produced: neural progenitor cells, neurons, neural aggregates, cerebral organoids, astrocytes, hematopoietic progenitor cells, and microglia. Fibroblasts can also be directly differentiated into neurons. A variety of these cell types can also be co-cultured to produce a more physiologically relevant system.
Differentiation capacity of Induced Pluripotent Stem Cells (iPSCs) into a variety of neurologically related cell types

iPSC Biomarker Core

For information regarding the mission of the iPSC Biomarker Core, click here

For additional questions on how to access our cell line repository, please contact Celeste Karch at karchc@wustl.edu or Jacob Marsh at jacobmarsh@wustl.edu

Dominantly Inherited Alzheimer’s Network

To learn more about the Dominantly Inherited Alzheimer’s Network, please visit the DIAN homepage. To request resources please visit the DIAN Resource Page.

To learn more about the collaboration between the Dominantly Inherited Alzheimer’s Network and the Karch Lab, click here

The Dominantly Inherited Alzheimer’s Network (DIAN) collects data related to Alzheimer’s disease through biomarker and genetic analysis, neural imaging, and clinical and cognitive data. The image depicts the following: 1. A human form labeled “clinical and cognitive” and showing the neural network; 2. A brain scan labeled “imaging” and listing the scanning procedures “Amyloid PET, Tau PET and MRI;” 3. Colored specimen collection tubes labeled CSF and plasma 4. Diagram of a skin biopsy, and immunocytochemistry stained images of the resulting Fibroblasts and iPSCs 5. A DNA double helix and web of connected dots to illustrate Genetic analysis through sequencing, WGS, epigenomics, transcriptomics, proteomics, lipidomics, and metabolomics.
The Dominantly Inherited Alzheimer’s Network (DIAN) collects data related to Alzheimer’s disease through biomarker and genetic analysis, neural imaging, and clinical and cognitive data

Knight Alzheimer’s Disease Research Center

To learn more about the Knight Alzheimer’s Disease Research Center, please visit the Knight ADRC homepage. To request resources please visit the Knight ADRC Resource Page.

To learn more about the collaboration between the Knight Alzheimer’s Disease Research Center and the Karch Lab, click here

FTD Center Without Walls (CWOW)

Our FTD CWOW goal is to understand the normal process of tau metabolism as a series of decisions made at regulatory nodes. The Karch lab is focusing on downstream aspects of tau metabolism and homeostasis that will reveal novel mechanisms underlying tauopathy. To learn more about our research with our FTD CWOW team, please visit the CWOW homepage.