Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice

Caballero B, Bourdenx M, Luengo E, Diaz A, Sohn PD, Chen X, Wang C, Juste YR, Wegmann S, Patel B, Young ZT, Kuo SY, Rodriguez-Navarro JA, Shao H, Lopez MG, Karch CM, Goate AM, Gestwicki JE, Hyman BT, Gan L, Cuervo AM. Acetylated tau inhibits chaperone-mediated autophagy and promotes tau pathology propagation in mice. Nat Commun. 2021 Apr 14;12(1):2238. doi: 10.1038/s41467-021-22501-9. PMID: 33854069; PMCID: PMC8047017.